FILE - In this July 27, 2020, file photo, nurse Kathe Olmstead prepares a shot that is part of a possible COVID-19 vaccine, developed by the National Institutes of Health and Moderna Inc., in Binghamton, N.Y. Moderna said Monday, Nov. 16, 2020, its COVID-19 shot provides strong protection against the coronavirus that’s surging in the U.S. and around the world. (AP Photo/Hans Pennink, File)

FILE - In this July 27, 2020, file photo, nurse Kathe Olmstead prepares a shot that is part of a possible COVID-19 vaccine, developed by the National Institutes of Health and Moderna Inc., in Binghamton, N.Y. Moderna said Monday, Nov. 16, 2020, its COVID-19 shot provides strong protection against the coronavirus that’s surging in the U.S. and around the world. (AP Photo/Hans Pennink, File)

VIDEO: 2nd coronavirus vaccine shows early success in U.S. tests

Moderna said its vaccine appears to be 94.5% effective, according to preliminary data

For the second time this month, there’s promising news from a COVID-19 vaccine candidate: Moderna said Monday its shots provide strong protection, a dash of hope against the grim backdrop of coronavirus surges in the U.S. and around the world.

Moderna said its vaccine appears to be 94.5% effective, according to preliminary data from the company’s still ongoing study. A week ago, competitor Pfizer Inc. announced its own COVID-19 vaccine appeared similarly effective — news that puts both companies on track to seek permission within weeks for emergency use in the U.S.

Dr. Stephen Hoge, Moderna’s president, welcomed the “really important milestone” but said having similar results from two different companies is what’s most reassuring.

“That should give us all hope that actually a vaccine is going to be able to stop this pandemic and hopefully get us back to our lives,” Hoge told The Associated Press.

“It won’t be Moderna alone that solves this problem. It’s going to require many vaccines” to meet the global demand, he added.

Prime Minister Justin Trudeau said in late October that Canada has signed six agreements with a number of companies taking part in the global race to produce a safe and effective vaccine for COVID-19, including Moderna and Pfizer.

Both of those American vaccine makers have asked Health Canada to review their products.

READ MORE: Pfizer says COVID-19 vaccine is looking 90% effective

A vaccine can’t come fast enough, as case totals in Canada are rapidly approaching the 300,000 mark, even as long-standing national virus hot spots Quebec and Ontario recorded declines in their daily tallies on Sunday.

In the United States, the case total topped 11 million over the weekend — 1 million of them recorded in just the past week. The pandemic has killed more than 1.3 million people worldwide, more than 245,000 of them in the U.S.

Still, if the U.S. Food and Drug Administration allows emergency use of Moderna’s or Pfizer’s candidates, there will be limited, rationed supplies before the end of the year. Both require people to get two shots, several weeks apart. Moderna expects to have about 20 million doses, earmarked for the U.S., by the end of 2020. Pfizer and its German partner BioNTech expect to have about 50 million doses globally by year’s end.

Moderna’s vaccine, created with the National Institutes of Health, is being studied in 30,000 volunteers who received either the real vaccination or a dummy shot. On Sunday, an independent monitoring board broke the code to examine 95 infections that were recorded starting two weeks after volunteers’ second dose — and discovered all but five illnesses occurred in participants who got the placebo.

The study is continuing, and Moderna acknowledged the protection rate might change as more COVID-19 infections are detected and added to the calculations. Also, it’s too soon to know how long protection lasts. Both cautions apply to Pfizer’s vaccine as well.

But Moderna’s independent monitors reported some additional, promising tidbits: All 11 severe COVID-19 cases were among placebo recipients, and there were no significant safety concerns.

READ MORE: Canada signs deals with Pfizer, Moderna to get doses of COVID-19 vaccines

The main side effects were fatigue, muscle aches and injection-site pain after the vaccine’s second dose, at rates that Hoge characterized as more common than with flu shots but on par with others such as shingles vaccine.

Moderna shares rocketed higher on the announcement and appeared to be headed for an all-time high Monday. The Cambridge, Massachusetts, company’s vaccine is among 11 candidates in late-stage testing around the world, four of them in huge studies in the U.S.

Both Moderna’s shots and the Pfizer-BioNTech candidate are so-called mRNA vaccines, a brand-new technology. They aren’t made with the coronavirus itself, meaning there’s no chance anyone could catch it from the shots. Instead, the vaccine contains a piece of genetic code that trains the immune system to recognize the spiked protein on the surface of the virus.

The strong results were a surprise. Scientists have warned for months that any COVID-19 shot may be only as good as flu vaccines, which are about 50% effective.

Another steep challenge: distributing doses that must be kept very cold. Both the Moderna and Pfizer shots are frozen but at different temperatures. Moderna announced Monday that once thawed, its doses can last longer in a refrigerator than initially thought, up to 30 days. Pfizer’s shots require long-term storage at ultra-cold temperatures.

___

The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content.

Lauran Neergaard, The Associated Press


Like us on Facebook and follow us on Twitter.

Want to support local journalism during the pandemic? Make a donation here.

Coronavirusvaccines

Just Posted

A report by investigator Mary Ellen Turpel-Lafond found “widespread systemic racism against Indigenous people” in a report released Monday.
Peninsula hospital one where ‘significant work underway’ to repair Indigenous relations

Investigation finds ‘widespread systemic racism against Indigenous people’ in provincial health care

Left to right: A screenshot of NTC nurse navigator Lesley Cerney, FNHA regional mental health manager Georjeana Paterson and Island Health’s medical health officer Dr. Charmaine Enns addressing Ehattesaht community members from Ehatis reserve in a Facebook live update. (Ehattesaht First Nation/Facebook)
Medical team sent to Ehatis reserve near Zeballos to guide community through COVID outbreak

17 cases, eight recoveries and no hospitalizations as Island Health praises First Nation’s response

An man from Errington died when his ATV went over an embankment on Northwest Bay Logging Road on the weekend. (File photo)
Errington man dies in ATV crash southwest of Parksville

Incident happened on Northwest Bay Logging Road on Saturday afternoon

Remains of the scene off Melrose Road in Whiskey Creek where three bodies were found on Nov. 1, 2020. (Mandy Moraes photo)
RCMP investigation continues into grisly discovery of 3 human bodies, 4 dead dogs near Whiskey Creek

Police still want to speak with motorist who picked up hitchhikers near scene on Nov. 1

Island Health has confirmed the first long term care facility outbreak in Greater Victoria at Veterans Memorial Lodge in Saanich. (Google Maps)
Island Health records first long-term care COVID outbreak in Greater Victoria

Veterans Memorial Lodge in Saanich confirms one positive staff member

A B.C. Ambulance Service paramedic wearing a face mask to curb the spread of COVID-19 moves a stretcher outside an ambulance at Royal Columbia Hospital, in New Westminster, B.C., on Sunday, November 29, 2020. THE CANADIAN PRESS/Darryl Dyck
B.C. records deadliest weekend of COVID-19 pandemic with 46 deaths; more than 2,300 cases

Provincial health officer Dr. Bonnie Henry provides COVID-19 update

A lightning strike destroyed a radio repeater on Porter Mountain, shutting down the Ministry of Transportation and infrastructure’s highway cam at Sutton Pass. (BC Transportation and Infrastructure photo)
Lightning strike shuts down camera on Tofino-Ucluelet highway

“One of our radio repeater sites was recently struck by lightning.”

Vehicles drive past a display thanking essential workers in Burnaby, B.C. on Sunday, Nov. 29, 2020. THE CANADIAN PRESS/Marissa Tiel
B.C. changing COVID-19 case reporting as virus spread continues

Manual counting takes more time, leads to errors

Three Ladysmith Health Care Auxiliary Thrift Store volunteers have tested positive for COVID-19. (Ladysmith Health Care Auxiliary photo)
Three Ladysmith Health Care Auxiliary Thrift Store volunteers test positive for COVID-19

Anyone who volunteered at Thrift Store between Nov. 14 - Nov. 28 is asked to monitor for symptoms

Victoria police issued tickets to two Victoria party hosts Saturday night, according to VicPD Chief Del Manak. (Unsplash)
Victoria partiers hid in closets, bedrooms in an attempt to avoid fines

Police gave out COVID-19 tickets to two separate parties

Parking fees at Sooke Potholes Regional Park will be going up at some point, but not without further discussion. Capital Regional District directors asked CRD staff to come back with alternatives after they proposed increasing the $2.25 per day rate to $7 for 2021. (TJ Watt photo)
Greater Victoria politicians ditch plan for $7 daily parking at two regional parks

Capital Regional District directors fear backlash from parks users

Patricia Kent, 25, was reported missing over the weekend, as her family has been unable to reach her, say police. (Photo submitted)
RCMP ask for help locating missing Nanaimo woman

Patricia Kent, 25, has not been seen nor heard from since Saturday, say police

Chemainus author Robyn Gerland. (Photo by Don Bodger)
Gerland shares personal story of the season

Chemainus author’s offering features in Chicken Soup for the Soul Christmas publication

Most Read