Dr. Bonnie Henry talks about phase two in B.C.’s COVID-19 immunization plan as Premier John Horgan and Minister Arian Dix look on during a press conference at Legislature in Victoria, B.C., on Monday, March 1, 2021. THE CANADIAN PRESS/Chad Hipolito

Dr. Bonnie Henry talks about phase two in B.C.’s COVID-19 immunization plan as Premier John Horgan and Minister Arian Dix look on during a press conference at Legislature in Victoria, B.C., on Monday, March 1, 2021. THE CANADIAN PRESS/Chad Hipolito

Vaccines: B.C. pushes ahead with delayed second doses as Ontario waits for national guidance

Dr. Bonnie Henry said she expects the national immunization committee to align with the province’s decision

Ontario is waiting for a recommendation from the National Advisory Committee on Immunization before delaying second doses of COVID-19 vaccines, while British Columbia is pushing ahead with its plan to extend the interval to four months.

A researcher whose work underpinned B.C.’s decision said Tuesday that the change was based on strong data. Dr. Danuta Skowronski, epidemiology lead of influenza and emerging respiratory pathogens at the B.C. Centre for Disease Control, said Pfizer-BioNTech underestimated the efficacy of the first dose of its own vaccine in its submissions to the U.S. Food and Drug Administration.

Skowronski said the company included data from the first two weeks after trial participants received the shot, which is a time when vaccines typically aren’t effective. When she and her colleagues adjusted the data, they made a surprising discovery.

“We took that into account and showed that the vaccine efficacy was not 52 per cent, it was actually 92 per cent. That was actually very similar, that first-dose efficacy, to what the other manufacturer, Moderna, had actually itself correctly analyzed in its own submissions to the FDA,” she said in an interview.

Skowronski said the four-month interval is based on the basic principles of vaccine science. The protection from a first dose of vaccine does not suddenly disappear, it gradually wanes over time, and scientists are typically more concerned about providing a second dose too soon rather than too late, she said.

“I think if the public had a chance to hear and to understand that, they would say, ‘OK, this is not messing around. This is really managing risk in a way that maximizes protection to as many Canadians as possible.’”

She said the province’s decision was backed up by data from Quebec, the United Kingdom and Israel, and comes at a time when B.C. residents are experiencing severe social and economic effects from isolation during the pandemic.

Skowronski added that the B.C. Centre for Disease Control also examined the effects of a single dose on long-term care residents and health-care workers in the province and found that it reduced the risk of the virus by 80 per cent within two to three weeks.

Provincial health officer Dr. Bonnie Henry has said she expects a statement from the national immunization committee aligning with the province’s decision, while Ontario Health Minister Christine Elliott said Tuesday she wanted to wait for such a recommendation.

She said extending the interval between doses would allow the province to get some level of protection to more people.

“This would be a considerable change,” she said.

“With the variants of concern out there, this could make a significant difference for Ontario in reducing hospitalizations and deaths. So, we are anxiously awaiting NACI’s review of this to determine what they have to say in their recommendations.”

Dr. Shelley Deeks, vice-chair of the national committee, said in an email the group is expected to issue a statement on extending the dose interval on Wednesday, but she did not confirm it would align with B.C.’s plan.

Alberto Martin, a University of Toronto immunology professor, said his understanding of a published Pfizer-BioNTech clinical trial was that the first dose provided 60 per cent protection and the second dose provided 95 per cent protection.

He said there is “obviously some concern” about B.C.’s plan because he is not aware of any clinical trial that examined a four-month gap between doses.

“There might be a risk that you’re not going to achieve that 95 per cent protection that the Pfizer-BioNTech vaccine can achieve with two doses separated by a few weeks apart,” he said.

However, he said difficult times — when the vaccine supply is so limited — require drastic measures.

“I think what they’re trying to do is immunize as many people as possible, get partial protection in the population and then hope for the best that the second dose that comes in four months later will boost the immune response enough to achieve that 95 per cent protection,” he said.

“It’s a difficult decision to make. I don’t know whether I’d like to be in that position, but I think it’s understandable why they’re doing this.”

Coronavirus

Just Posted

Berwick by the Sea resident Hilda Shilliday, 91, is ready to participate in the Grandmothers to Grandmothers’ Stride to turn the Tide fundraising event that runs April 11-25. Register on the event website for a fee of $20 which goes to support the Stephen Lewis Foundation’s work in Africa, then do any kind of exercise, log the time, distance or whatever and be eligible for a prize package. Photo contributed
91-year-old Vancouver Islander ready to Stride to Turn the Tide

Campbell River’s Hilda Shilliday encourages everyone to support African grandmothers

Exterior of Highland Manor shows at least one broken window, covered with a blanket. (Zoe Ducklow/News Staff)
Reclaiming blighted Vancouver Island apartment complex requires more than paint

Improvements to Port Hardy’s troubled Highland Manor are slow and stuck in red tape

Kit Thornton, chief aquarist at the Shaw Centre for the Salish Sea, plays with Wanda, the female Giant Pacific octopus currently residing at the centre. The centre will release Wanda back into the wild next month. (Wolf Depner/News Staff)
An octopus named Wanda will soon say goodbye to Sidney

Wanda’s personality is ‘complete opposite’ of previous octopus named after Dr. Bonnie Henry

Carson Grant, general manager of Comox Valley Dodge regularly reaches out to people to assist with vehicles, food, clothes and more. Google Maps photo
Vancouver Islander getting back on her feet thanks to kindness of her community

Woman was living in her broken-down truck in Comox Valley when her call for help was answered

The Town of Lake Cowichan wants to get more people out of their cars. That should be the goal of all of the transportation plans currently under review in the Cowichan Valley. (Gazette file)
Editorial: Time to dream up better transportation options

Vancouver Island needs to ask ‘how are we going to get there from here?’

B.C. Health Minister Adrian Dix and Premier John Horgan describe vaccine rollout at the legislature, March 29, 2021. (B.C. government)
1,262 more COVID-19 infections in B.C. Friday, 9,574 active cases

Province’s mass vaccination reaches one million people

Tyson Ginter, 7, is proud of his latest Hot Wheels he recently received by Quesnel RCMP Const. Matt Joyce. (Photo submitted)
B.C. Mountie handing out toy cars to light up children’s faces

‘A lot of times it will be the only interaction they have with the police,’ says Const. Matt Joyce

Chief Public Health Officer Theresa Tam speaks during a technical briefing on the COVID pandemic in Canada, Friday, January 15, 2021 in Ottawa. THE CANADIAN PRESS/Adrian Wyld
Canada’s ICUs see near-record of COVID-19 patients last week as variant cases double

Last week, Canadian hospitals treated an average of 2,500 patients with COVID-19, daily, up 7% from the previous week

University of Victoria rowing coach Barney Williams at the University of Victoria in Victoria, B.C. THE CANADIAN PRESS/Chad Hipolito
UVic, women’s rowing coach deny former athlete’s allegation of verbal abuse

Lily Copeland alleges coach Barney Williams would stand close to her and speak aggressively in the sauna

Librarian Katie Burns with the Fraser Valley Regional Libraries poses for a photo in Chilliwack on June 18, 2019. Monday, April 12, 2021 is Library Workers’ Day. (Jenna Hauck/ Chilliwack Progress file)
Unofficial holidays: Here’s what people are celebrating for the week of April 11 to 17

Library Workers Day, That Sucks! Day, and Wear Your Pyjamas to Work Day are all coming up this week

The City of Parksville encourages residents to visit outdoor restaurant patios as part of a social media challenge. (Submitted photo)
Parksville promotes patio patrons to post pictures to support restaurant industry

Patio Challenge: Take a photo of your food for social media

Campbell River’s Repair Cafe is on once again next week at the Sportsplex. It’ll just look a little different than people are used to. Mirror File Photo
Got a broken thing? Repair Cafe is once again looking for stuff to fix

Annual Campbell River service will be a drop-off/pick-up situation due to COVID-19 protocols

Anna Wu, a young golfer from Victoria, came in second at the Masters’ Drive, Chip and Putt challenge at the Augusta National Golf Club on March 4. (Photo courtesy of Kevin C. Cox/Getty Images)
Victoria golfer places second at Masters’ Drive, Chip and Putt youth competition

Anna Wu’s chipping challenge hole out was praised by Masters champ Phil Mickelson

‘Frank Ney’ by Patrick Flavin, ‘Millstone River Upper Falls’ by John Collison Baker, ‘Labyrinth of Dreams’ by MA Molcan, ‘On the Other Side’ by Liana Ravensbergen, ‘December Snow’ by Laurel Karjala and ‘Jacks Point’ by Dana Smiley (cropped, clockwise from top-left) are among the works in the Nanaimo Arts Council’s latest exhibition. (Photos courtesy Nanaimo Arts Council)
Nanaimo Arts Council presents its first online gallery show

Submissions now open for upcoming ‘Ekphrastic Celebration’ show

Most Read